Why the study?
Does altered arterial load (increased resistance, decreased compliance, or increased reflections) impair left ventricular performance and energetics in a computational model?
Population
Computational model of the left ventricle and arterial system
Comparison
Increase in arterial resistance, decrease in… vs Baseline model parameters
Design
Preclinical
Authors
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Hypothesis-generating for arterial load targets in LV dysfunction; leaves open human validation of resistance-dominant effects on stroke output.
Does altered arterial load (increased resistance, decreased compliance, or increased reflections) impair left ventricular performance and energetics in a computational model?
A computational model demonstrates that reduced arterial compliance and early wave reflections impair ventricular-arterial coupling and left ventricular energy efficiency.
David Fitchett (1991) studied this question.
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