Why the study?
Opioid side effects are a major concern in the postoperative period in children, and the opioid-sparing effect of NSAIDs remains controversial.
Does perioperative NSAID administration reduce opioid consumption and postoperative nausea and vomiting in children and infants?
Meta-Analysis
Does perioperative NSAID administration reduce opioid consumption and postoperative nausea and vomiting in children and infants?
Standardized Mean Difference: -0.66 (95% CI -0.84–-0.48)
Perioperative NSAID administration in children effectively reduces postoperative opioid consumption and the incidence of postoperative nausea and vomiting.
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A 2012 study conducted a meta-analysis in Postoperative pain. NSAIDs vs. Control was evaluated on Postoperative opioid requirement in the PACU (SMD -0.66, 95% CI -0.84 to -0.48).
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