Key result
High contrast volume-to-creatinine clearance ratio is linked to an ~18% rate of contrast-induced nephropathy.
Why the study?
Improved prediction of contrast-induced nephropathy after PCI in patients with reduced ejection fraction was needed.
Does the contrast volume-to-creatinine clearance ratio predict the risk of contrast-induced nephropathy in patients with reduced ejection fraction undergoing PCI?
Observational (n=111)
Does the contrast volume-to-creatinine clearance ratio predict the risk of contrast-induced nephropathy in patients with reduced ejection fraction undergoing PCI?
p-value: p=.013
A contrast volume-to-creatinine clearance ratio ≥3.87 is an independent predictor of contrast-induced nephropathy in patients with reduced ejection fraction undergoing PCI, suggesting a useful cutoff for risk stratification.
We determined a relatively safe contrast media volume-to-creatinine clearance (V/CrCl) cutoff value to avoid contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients (n = 111) with reduced ejection fraction (<40%). Improved prediction of CIN in these patients would be useful. Multivariate regression models were used to evaluate whether V/CrCl is an independent risk factor for CIN. Nine (8.1%) patients developed CIN. The V/CrCl was significantly (P = .023) higher in patients with CIN than in those without. The incidence of CIN in patients with the highest tertile of V/CrCl was significantly higher than the middle and lowest tertiles (18.4% vs. 2.7% and 2.8%; P = .013). After adjusting for other potential risk factors, a V/CrCl ≥3.87 remained significantly associated with risk of CIN. A V/CrCl <3.87 might be valuable in predicting the risk of CIN in patients with reduced ejection fraction undergoing PCI.
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Liu et al. (2014) conducted an observational in Reduced ejection fraction undergoing percutaneous coronary intervention (n=111). High contrast volume-to-creatinine clearance (V/CrCl) ratio vs. Lower V/CrCl ratio was evaluated on Contrast-induced nephropathy (CIN) (p=.013). A highest tertile contrast volume-to-creatinine clearance ratio was associated with increased contrast-induced nephropathy compared to middle and lowest tertiles (18.4% vs 2.7% and 2.8%; P=0.013).
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