Key result
Isolated CABG is linked to moderate ischemic mitral regurgitation regression in ~57% of patients.
Why the study?
The optimal treatment protocol for patients with moderate ischemic mitral regurgitation undergoing coronary artery bypass surgery is under debate.
Does isolated coronary artery bypass surgery improve mitral regurgitation in patients with moderate ischemic mitral regurgitation and coronary artery disease?
Cohort (n=47)
Does isolated coronary artery bypass surgery improve mitral regurgitation in patients with moderate ischemic mitral regurgitation and coronary artery disease?
Isolated coronary artery bypass surgery in patients with moderate ischemic mitral regurgitation leads to regression of MR to a mild degree in over half of patients, with acceptable survival rates.
May support isolated CABG alone for moderate ischemic MR; leaves open need for RCTs to define optimal mitral intervention.
BACKGROUND: Mitral valve intervention combined with coronary artery bypass surgery is inevitable in the case of severe mitral regurgitation in patients with coronary artery disease because the prognosis is poor without mitral correction. The best treatment protocol for patients with a moderate degree of mitral regurgitation is under debate. To clarify the optimal management for these patients, we evaluated the progress of mitral regurgitation after isolated coronary artery bypass surgery in cases of ischemic mitral regurgitation. METHODS; The study was conducted between March 2001 and April 2003. Forty-seven patients (70% men, with a mean age of 61 years, a mean ejection fraction of 43.7%, and a mean New York Heart Association class of 2.53) with preoperative diagnoses of moderate degree ischemic mitral regurgitation (Grade 3 mitral regurgitation on a scale of 0 to 4) and coronary artery disease, without leaflet pathology, underwent isolated coronary artery bypass surgery. Patients were followed-up at a mean of 22 months and an echocardiographic evaluation was done to determine the progress of the mitral disease. RESULTS: The 30-day operative mortality rate was 2.1%. In the postoperative period, the mean ejection fraction was 46.9% and the mean functional capacity of the patients was 1.31. Mitral regurgitation regressed to a mild degree in 56.9% of the patients. The 2-year survival rate was 93.7%. CONCLUSIONS: Patients with moderate ischemic mitral regurgitation and coronary artery disease who underwent coronary artery bypass surgery alone had acceptable results. We are of the opinion that isolated coronary artery bypass surgery might be a good treatment choice for moderate degree ischemic mitral regurgitation.
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Gürbüz et al. (2006) conducted a cohort in Moderate degree ischemic mitral regurgitation and coronary artery disease (n=47). Isolated coronary artery bypass surgery was evaluated on Regression of mitral regurgitation to a mild degree. Isolated coronary artery bypass surgery resulted in regression to mild mitral regurgitation in 56.9% of patients with moderate ischemic mitral regurgitation and coronary artery disease.
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