Key result
T1w-SPACE strongly correlates with CE-MRA for lumen area and detects greater vessel wall area in PAD.
Why the study?
The feasibility of a multi-station 3D T1-weighted turbo spin echo dark-blood SPACE sequence to assess inflow vessels in peripheral arterial disease compared with CE-MRA was evaluated.
Does T1w-SPACE imaging provide comparable lumen area measurements to CE-MRA and allow assessment of vessel wall characteristics in patients with peripheral arterial disease?
Observational (n=20)
Does T1w-SPACE imaging provide comparable lumen area measurements to CE-MRA and allow assessment of vessel wall characteristics in patients with peripheral arterial disease?
Effect estimate: r > 0.9
p-value: p=<0.001
T1w-SPACE is a feasible imaging modality that correlates strongly with CE-MRA for lumen assessment while providing additional capability to evaluate atherosclerotic plaque and vascular remodeling in peripheral arterial disease.
Supports T1w-SPACE for non-contrast PAD vessel assessment; leaves open prospective validation before clinical use.
PURPOSE: To evaluate the feasibility of a multi-station three dimensional (3D) T1-weighted turbo spin echo (TSE) dark-blood Sampling Perfection with Application optimized Contrasts using different flip angle Evolution sequence (T1w-SPACE), to assess aorta, iliac, and superficial femoral (SFA) arteries (inflow vessels) by comparing it with a multi-station contrast enhanced MR angiography (CE-MRA) with identical resolution. MATERIALS AND METHODS: A total of 6 volunteers and 14 peripheral arterial disease (PAD) patients were included in the study. Abdominal and thigh T1w-SPACE and lower leg time-resolved MRA (TR-MRA) with low dose contrast were followed by 3-station CE-MRA. Quantitative measurements of lumen area at 17 locations from T1w-SPACE and CE-MRA were obtained. Additionally, vessel wall areas at the same locations were obtained from the T1w-SPACE images. RESULTS: Quantitative comparison of lumen areas with T1w-SPACE and CE-MRA revealed strong correlation between the two techniques and strong inter-observer agreement for each of the two imaging methods (r > 0.9; P < 0.001). Localized vessel wall area measurements obtained in PAD patients were significantly greater compared with those obtained in normal volunteers (mean difference 43.75 +/- 12.46 mm(2); P < 0.001). Stenosis severity obtained from T1w-SPACE localized measurements showed significant arterial area stenosis in PAD patients. CONCLUSION: T1w-SPACE imaging of inflow vessels is feasible, and in addition to CE-MRA has the ability to assess atherosclerotic plaque and vascular remodeling.
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Mihai et al. (2009) conducted an observational in Peripheral arterial disease (n=20). T1w-SPACE imaging vs. Contrast enhanced MR angiography (CE-MRA) was evaluated on Quantitative measurements of lumen area (r > 0.9, p=<0.001). T1w-SPACE imaging demonstrated strong correlation with CE-MRA for lumen area measurements (r > 0.9; P < 0.001) and identified greater vessel wall areas in PAD patients versus normal volunteers.
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