Key result
Pulmonary microvascular cytology detects malignant cells in ~57% of suspected pulmonary tumor embolism cases.
Why the study?
Pulmonary tumor embolism and intravascular lymphoma cause rapid deterioration and are difficult to diagnose antemortem, with limited data on pulmonary microvascular cytology utility.
Is pulmonary microvascular cytology useful in diagnosing pulmonary tumor embolism and intravascular lymphoma?
Case Report (n=7)
No
Is pulmonary microvascular cytology useful in diagnosing pulmonary tumor embolism and intravascular lymphoma?
Pulmonary microvascular cytology may be a useful diagnostic tool for identifying pulmonary tumor embolism and intravascular lymphoma.
May aid diagnosis of pulmonary tumor embolism; hypothesis-generating and requires prospective validation.
Pulmonary tumor embolism (PTE) and intravascular lymphoma cause rapidly progressive deterioration and an antemortem diagnosis is difficult. The usefulness of pulmonary microvascular cytology (PMC) in the diagnosis of these disorders has been reported in sporadic case reports. We retrospectively evaluated the records of 7 patients with tumor cells in the pulmonary microvasculature (4 with PTE and 3 with malignant lymphoma) who underwent pulmonary microvascular cytology. Two of the 4 patients with PTE and 2 of the 3 patients with malignant lymphoma (all 3 had intravascular metastasis) had positive PMC results. These findings suggested that PMC may be useful in the diagnosis of these disorders.
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Ishiguro et al. (2016) conducted a case report in Pulmonary tumor embolism and intravascular lymphoma (n=7). Pulmonary microvascular cytology was evaluated on Detection of tumor cells (positive PMC result). Pulmonary microvascular cytology successfully detected tumor cells in 4 of 7 patients (57.1%) with pulmonary tumor embolism or intravascular lymphoma.
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