Key result
Linear radiofrequency lesions eliminate AF by prolonging fibrillatory cycle length without altering wavelet dynamics.
Why the study?
The mechanisms by which atrial linear ablation lesions eliminate atrial fibrillation are not fully understood.
Does linear radiofrequency ablation alter electrophysiological parameters to eliminate atrial fibrillation in dog models?
Comparison
Before and after linear radiofrequency ablation lesions in both atria
Design
Preclinical study with epicardial mapping
Authors
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Linear lesions may terminate AF by prolonging cycle length in canine models; leaves open mechanisms for human ablation.
Does linear radiofrequency ablation alter electrophysiological parameters to eliminate atrial fibrillation in dog models?
In canine models, linear ablation lesions eliminate atrial fibrillation by increasing fibrillatory cycle length rather than altering conduction velocity or wavelet complexity.
Sih et al. (1997) studied Atrial fibrillation (n=15). Linear radiofrequency ablation lesions vs. Before ablation was evaluated on Electrophysiological parameters (conduction velocity, wavelet characteristics, fibrillatory cycle length). Linear radiofrequency ablation lesions eliminated atrial fibrillation by increasing the fibrillatory cycle length without changing conduction velocity or the number, size, and complexity of wavelets.
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