Left Atrial Appendage Occlusion—Is the Case Now Closed?

Q: What does this research mean for the field?

Findings from the CLOSURE-AF and CHAMPION-AF trials should directly guide clinical decision-making regarding the comparative use of direct oral anticoagulants versus left atrial appendage closure. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

David Seiffge; Richard A. Bernstein; Rod S. Passman; Charlotte Cordonnier

doi:10.1001/jamaneurol.2026.3292

September 28, 2026JAMA Neurology

Left Atrial Appendage Occlusion—Is the Case Now Closed?

View at Publisher

Ask AI

Bookmark

Share

Key result

Left atrial appendage closure versus direct oral anticoagulants requires careful clinical decision-making informed by the recent CLOSURE-AF and CHAMPION-AF trial results.

Why the study?

How should the results of CLOSURE-AF and CHAMPION-AF inform decision-making regarding treatment with direct oral anticoagulants versus left atrial appendage closure?

Key Points

Examine how recent evidence from the CLOSURE-AF and CHAMPION-AF trials should guide clinical decision-making between left atrial appendage occlusion and direct oral anticoagulants.
Expert clinical viewpoint analyzing published and emerging data from the CLOSURE-AF and CHAMPION-AF clinical trials.
Evaluation of therapeutic trade-offs between mechanical left atrial appendage closure and pharmacological anticoagulation.
Findings from CLOSURE-AF and CHAMPION-AF provide critical comparative evidence to reassess the balance between ischemic stroke prevention and procedural versus bleeding complications.
Clinical decision-making increasingly requires individualized risk stratification rather than viewing either mechanical occlusion or direct oral anticoagulation as universally superior.

Structured PICO

How should the results of CLOSURE-AF and CHAMPION-AF inform decision-making regarding treatment with direct oral anticoagulants versus left atrial appendage closure?

I

Intervention

Left atrial appendage closure

C

Comparator

Direct oral anticoagulants

Implication

This Viewpoint discusses how the results of CLOSURE-AF and CHAMPION-AF should inform decision-making regarding treatment with direct oral anticoagulants vs left atrial appendage closure.

Abstract

This Viewpoint disucsses how the results of CLOSURE-AF and CHAMPION-AF should inform decision-making regarding treatment with direct oral anticoagulants vs left atrial appendage closure for left atrial appendage occlusion.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Seiffge et al. (2026) studied this question. Left atrial appendage closure versus direct oral anticoagulants requires careful clinical decision-making informed by the recent CLOSURE-AF and CHAMPION-AF trial results.

synapsesocial.com/papers/6abc576efbfca106a1247ec5 https://doi.org/10.1001/jamaneurol.2026.3292