Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 28, 2013Heart RhythmOpen Access

Left atrial appendage closure: A new technique for clinical practice

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does left atrial appendage closure reduce stroke risk compared to oral anticoagulation in patients with atrial fibrillation?

Population

Patients with atrial fibrillation at high risk for stroke who cannot tolerate oral anticoagulation or…

Comparison

Left atrial appendage closure vs Oral anticoagulation (e.g., warfarin)

Design

Review

Authors

ACA. John CammACAntonio ColomboGCG. Corbucci

Discussion

Loading...

Member takes

Overview

May inform decisions for anticoagulant-intolerant AF patients; leaves open need for head-to-head RCTs versus OAC.

Structured PICO

Does left atrial appendage closure reduce stroke risk compared to oral anticoagulation in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation at high risk for stroke who cannot tolerate oral anticoagulation or present problems managing drug treatment
I
Intervention
Left atrial appendage closure (surgical and transcatheter devices, including WATCHMAN)
C
Comparator
Oral anticoagulation (e.g., warfarin)
O
Outcome
Stroke risk reductionhard clinical

Left atrial appendage closure is a valid alternative to oral anticoagulation for stroke prevention in high-risk atrial fibrillation patients who cannot tolerate or manage anticoagulant therapy.

Limitations

  • Lack of large-scale randomized trials on long-term stroke risk
  • Most studies are relatively small

Cite This Study

Camm et al. (2013) studied this question.

synapsesocial.com/papers/6a77d50d7d04941475ae75cbhttps://doi.org/10.1016/j.hrthm.2013.11.030
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left atrial appendage closure: A therapy uniquely suited for specific populations of patients with atrial fibrillation2019 · 16 citations
  2. 2Current methods of left atrial appendage closure: the non-pharmacological approach for stroke prevention in atrial fibrillation patients2023
  3. 3Left atrial appendage closure: a percutaneous transcatheter approach for stroke prevention in atrial fibrillation2011 · 108 citations
  4. 4Left atrial appendage closure devices: a contemporary review of techniques, tips and tricks2026
  5. 5Left Atrial Appendage Closure: A Narrative Review2023 · 8 citations