Analysis of Cardiac Troponin I Elevation in Inpatients With Rhabdomyolysis Based on a Multicenter Retrospective Cohort Study

Objective This multicenter retrospective cohort study aimed to investigate the prevalence of cardiac troponin I (cTnI) elevation among hospitalized patients with rhabdomyolysis (RM) in China and to identify associated influencing factors. Methods A total of 214 inpatients with RM who were admitted to the hospital between January 2015 and December 2024 were enrolled. Based on their cTnI test results, patients were divided into cTnI‐positive and cTnI‐negative groups. Age, sex, body mass index (BMI), and other clinical indicators were compared between the two groups. Results Of the 214 patients, 29 had positive cTnI results, corresponding to a positive rate of 13.55%. Univariate analysis showed that age, creatine kinase (CK) level, and the proportion of patients receiving dialysis were significantly higher in the cTnI‐positive group than in the cTnI‐negative group. In contrast, the proportions of patients with normal electrocardiograms and those with causes such as intense exercise or crayfish consumption were significantly lower in the cTnI‐positive group ( p < 0.05). No significant differences were observed between the groups in sex, BMI, hypertension, smoking, diabetes, or other variables ( p > 0.05). Multivariate logistic regression analysis demonstrated that dialysis treatment and abnormal electrocardiogram were independent risk factors for cTnI positivity ( p < 0.05), whereas advanced age, elevated CK levels, and vigorous exercise were not statistically significant independent influencing factors. Conclusion cTnI elevation is relatively common among hospitalized patients with RM. The underlying mechanism is complex and may be associated with dialysis treatment, abnormal electrocardiogram findings and other factors.