Key result
Early coronary stenosis patterns differ by sex, with significant disease developing in ~50% of high-risk women.
Why the study?
The study aimed to identify individuals with increased frequency of early stenosing atherosclerosis symptoms in high-risk CHD patients with multifocal atherosclerosis considering comorbid abnormalities.
Observational
The study identifies specific gender-based patterns in coronary artery lesions among high-risk patients with multifocal atherosclerosis, with women showing more PKA stenosis and men showing more LCA branch lesions.
Cluster analysis of symptoms in high-risk CHD with MFA is hypothesis-generating; leaves open prospective validation before any clinical application.
The aim of the study was to identify individuals with increased frequency of early symptoms of stenosing atherosclerosis of the coronary arteries with consideration of the peculiarities of comorbid abnormalities in CHD patients high risk with the presence of MFA. Materials and methods. Patients of middle age were divided into 3 clusters by the method of hierarchical analysis of categorical variables according to the clinical manifestation of atherosclerotic lesions of the heart, brain and arteries of the lower extremities. Patients evaluated the clinical status, ECG, CAG, echodopplerography carotid and lower limb arteries. According to the indications, magnetic resonance imaging of the chest and abdomen, spirography, fibro-gastroduodenoscopy, ultrasound of the abdominal cavity and kidneys, if necessary, ultrasound of the pelvis were performed. Results. It was found that one of the manifestations of coronary artery disease was ACS with hemodynamically significant PKA stenosis (76-90%), which developed in 50% of women with primary lesion of the 3rd segment of PKA, belonging to the 3rd cluster of the examined. The structure of hemodynamically significant changes in LCA branches was dominated by men of the 1st cluster with lesions of the 6th segment of PHA, DV, 15 segment of OA, while unstable angina was established in 54,2% of them, in the anamnesis - in 51,1%. Frequency of the level of the border of stenosis (50-75%) branches LKA showed a male predominance of the 1-St cluster with a lesion of the 6th segment PMRA involving DV and 15 of the OA segment, coupled with clinic stable angina. Conclusion. The nature of coronary vessels lesions in men and women of the middle age category revealed persons with an increased frequency of signs of stenotic remodeling, taking into account the clinical symptoms and features of vascular comorbid burden in patients with high-risk IHD with the presence of MFA.
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Khasanov et al. (2018) conducted an observational in High-risk coronary heart disease with multifocal atherosclerosis. Gender vs. Men vs Women was evaluated on Characteristics of early stenotic lesions of coronary arteries. Gender differences in coronary artery lesions were observed, with hemodynamically significant stenosis developing in 50% of women in cluster 3 and predominantly in men in cluster 1.
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