Key result
Accelerometer-based pacing delivers proportional rate responses up to a mean of ~104 ppm during exercise.
Why the study?
An accelerometer-based rate adaptive pacemaker system was introduced and its clinical performance during daily activities and exercise required evaluation.
Does an accelerometer-based rate adaptive pulse generator provide proportional pacing rate responses to graded activities in patients requiring pacing?
Observational (n=29)
Does an accelerometer-based rate adaptive pulse generator provide proportional pacing rate responses to graded activities in patients requiring pacing?
An accelerometer-based rate adaptive pacemaker provides appropriate and proportional heart rate responses to various daily activities and exercise.
Supports accelerometer-based rate adaptation in early human testing; hypothesis-generating and should not yet change practice.
An accelerometer-based rate adaptive generator (EXCEL VR) has been introduced. A preclinical group of 22 subjects with strap-on devices was observed and reported. A clinical protocol including observation of rate adaptive response to typical daily activities and incremental exercise on a treadmill was administered in seven implanted patients. Indications for implantation in these patients was either second- or third-degree atrioventricular block (five patients, VVIR pacing mode) and sick sinus syndrome (two patients, AAIR pacing mode). Mean pacing rates were 50 ppm (supine), 56 ppm (standing), 77 ppm (descending the stairs), 81 ppm (slow walk), 83 ppm (slow stair climb), 91 ppm (fast walk), and 92 ppm (fast stair climb). When the arm proximal to the pulse generator was exercised, the rate rose to 92 ppm. When the distal arm was strained, the rate was 63 ppm. During treadmill testing, rates between 82 ppm (2 km/hour) and 104 ppm (5 km/hour) were observed. This accelerometer-based rate adaptive pulse generator provided a proportional response to graded activities of treadmill exercise and daily living in these groups of preclinical and clinical subjects.
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ERDELITSCH‐REISER et al. (1992) conducted an observational in Second- or third-degree atrioventricular block and sick sinus syndrome (n=29). Accelerometer-based rate adaptive generator (EXCEL VR) was evaluated on Rate adaptive response to typical daily activities and incremental exercise. The accelerometer-based rate adaptive pulse generator provided a proportional pacing rate response to graded activities, with mean rates ranging from 50 ppm supine to 104 ppm during exercise.
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