Key result
Platelet HDL receptor expression is ~50% lower in patients with CAD vs healthy controls.
Why the study?
The level of HDL receptor hSR-B1/CLA-1 expression on platelets in CAD patients with atherosclerotic disease and its relationship to coronary heart disease risk was not well characterized.
Case-Control (n=51)
No
Absolute Event Rate: 6.84% vs 13.6%
p-value: p=<0.001
The expression of HDL receptor hSR-B1/CLA-1 on platelets is significantly decreased in patients with coronary artery disease, suggesting its potential as a laboratory marker for CAD.
Reduced platelet hSR-B1/CLA-1 associates with CAD; leaves open its value as biomarker or target pending prospective studies.
The human scavenger receptor B1 (hSR-B1/CLA) is a HDL receptor with various anti-atherogenic functions which is expressed on the platelet surface. The anti thrombotic function of HDL includes the modulation of platelet reactivity, coagulation, and endothelial function. The goal of this study is to detect the level of HDL receptor on platelets of CAD patients with atherosclerotic disease. Expressions of the hSRB1 receptor on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls was detected using flow cytometry. Moreover, the lipid panel tests were assayed by Chemistry auto analyzer and compared with healthy controls. Our findings show that abundance of hSR-B1/CLA-1 was significantly reduced on the surface of platelets from CAD patients with atherosclerotic disease compared with healthy control (6/8 % vs. 13/6 %), (P <0,001). The HDL receptor (hSR-B1/CLA-1) expression on platelets inversely correlates with the risk of coronary heart disease. Our findings suggest that determining the level of hSR-B1/CLA-1 on the platelets may be a useful laboratory marker for CAD investigation.
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Nehzati et al. (2017) conducted a case-control in Coronary artery disease (CAD) (n=51). Coronary artery disease with atherosclerotic plaque vs. Healthy controls was evaluated on Expression of hSR-B1/CLA-1 (HDL receptor) on the surface of platelets (p=<0.001). The expression of the HDL receptor hSR-B1/CLA-1 was significantly reduced on the surface of platelets from patients with coronary artery disease compared to healthy controls (6.84% vs 13.6%, p<0.001).
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