Key result
Antipyretic treatment resolves fever-induced type 1 Brugada pattern in a rare presentation.
Why the study?
Fever is a recognized trigger that can unmask Brugada-like ECG changes mimicking Brugada syndrome without underlying congenital channelopathy.
Case Report (n=1)
No
Fever can induce a reversible type 1 Brugada-like ECG pattern (Brugada phenocopy) that resolves upon defervescence, highlighting the importance of treating the underlying trigger to avoid unnecessary ICD implantation.
May prompt ECG recheck after defervescence to avoid misdiagnosis; leaves open prospective validation of phenocopy management.
Background: Brugada phenocopy (BrP) refers to reversible electrocardiographic (ECG) patterns that mimic Brugada syndrome (BrS) in the absence of an underlying congenital channelopathy. Fever is a recognized trigger that can unmask Brugada-like ECG changes, particularly in older adults.Case Report: An 83-year-old man presented to the emergency department with fever and respiratory symptoms. Initial ECG demonstrated a type 1 Brugada-like pattern. Laboratory evaluation revealed inflammatory markers consistent with infection. Following antipyretic treatment and normalization of body temperature, repeat ECG showed complete resolution of the Brugada-like changes. The patient was monitored in the cardiology unit without arrhythmic events.Conclusion: This case highlights fever as a reversible cause of Brugada phenocopy in an elderly patient. Prompt recognition and treatment of the underlying trigger are essential to avoid unnecessary invasive interventions such as implantable cardioverter-defibrillator implantation.
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Ağaçkıran et al. (2026) conducted a case report in Brugada phenocopy (n=1). Fever vs. Normothermia was evaluated on Resolution of Brugada-like ECG changes. Fever induced a reversible type 1 Brugada-like ECG pattern in an 83-year-old man, which completely resolved following antipyretic treatment and normalization of body temperature.
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