What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy individuals (n=69). Intervention: Active sports participation vs. Sedentary lifestyle. Primary outcome: CK-MB values (U/L) (MD 0.50, 95% CI 0.102-0.889, p=0.014).

What does this research mean for the field?

Active male athletes have higher baseline CK-MB levels than sedentary men, whereas cardiac biomarker differences between active and sedentary women are not statistically significant. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine and compare resting CK-MB and hsTnI values between individuals who exercise regularly and those with a sedentary lifestyle, accounting for sex differences.

October 1, 2026Progress in nutritionOpen Access

Comparison of Creatine Kinase Myocardial Band (CK-MB) and High Sensitive Troponin I (hsTnI) Values Between Athletes and Sedentary People

Q: What are the key findings of this study?

Active sports participation was associated with significantly higher baseline CK-MB levels compared to a sedentary lifestyle (1.95 vs 1.45 U/L, p=0.014) in healthy young adults.

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Key result

Active sports participation is linked to ~34% higher baseline CK-MB levels in healthy young adults.

MD +0.50
95% CI 0.102-0.889
P=0.014
n=69

Why the study?

Differences in CK-MB and hsTnI values between active athletes and sedentary individuals, considering sex-related factors, were not well characterized.

Does regular active sports participation increase baseline CK-MB and hsTnI values compared to a sedentary lifestyle in healthy adults?

Key Points

To examine and compare resting CK-MB and hsTnI values between individuals who exercise regularly and those with a sedentary lifestyle, accounting for sex differences.
The test group included 35 active athletes (18 men, 17 women; 23.28±4.09 years) involved in team sports (n=20) or individual sports (n=15).
The control group included 34 sedentary individuals (17 men, 17 women; 24.50±5.60 years) who did not engage in any sport.
Biochemical parameters were evaluated in SPSS using the Independent Samples t Test and Welch's t test for independent groups.
Active athletes showed significantly higher CK-MB levels (1.95±1.04 U/L) than sedentary controls (1.45±0.49 U/L; mean difference 0.50, 95% CI 0.102 to 0.889, Cohen's D = 0.608, p = 0.014).
hsTnI values were significantly higher in the test group (1.95±1.61) than the control group (1.33±0.78; mean difference 0.62, 95% CI 0.015 to 1.238, Cohen's D = 0.494, p = 0.045).
Values were significantly higher in men than in women for both CK-MB and hsTnI (p<0.001), with men in the athlete group reaching CK-MB of 2.69±0.88 and hsTnI of 2.86±1.88 compared to 1.76±0.46 and 1.68±0.91 in sedentary men.

Study Design

Type

Cross-Sectional (n=69)

Multicenter

Structured PICO

Does regular active sports participation increase baseline CK-MB and hsTnI values compared to a sedentary lifestyle in healthy adults?

Population

69 healthy young adults (mean age 23.9 years, 49.3% female) without acute or chronic health problems, evaluated to compare cardiac biomarkers between active athletes and sedentary individuals.

Exposure

Regular active sports/exercise

Comparator

Sedentary lifestyle (no sports)

Outcome

Serum Creatine Kinase Myocardial Band (CK-MB) and high sensitive Troponin I (hsTnI) valuessurrogate

Main Result

Mean Difference: 0.5 (95% CI 0.102–0.889)

Absolute Event Rate: 1.95% vs 1.45%

p-value: p=0.014

Regular exercise is associated with higher baseline levels of cardiac biomarkers (CK-MB and hsTnI) in healthy individuals, particularly in men, which should be considered when interpreting these tests in clinical settings.

Limitations

Small sample size
Cross-sectional design
Lack of long-term follow-up or cardiovascular event data
Potential confounding by specific types of sports or exercise intensity

Discussion

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Implication

May necessitate caution interpreting CK-MB in active young adults; leaves open sex- and exercise-specific effects on hsTnI reference values.

Cite This Study

ÇAKAROĞLU et al. (2020) conducted a cross-sectional in Healthy individuals (n=69). Active sports participation vs. Sedentary lifestyle was evaluated on CK-MB values (U/L) (MD 0.50, 95% CI 0.102-0.889, p=0.014). Active sports participation was associated with significantly higher baseline CK-MB levels compared to a sedentary lifestyle (1.95 vs 1.45 U/L, p=0.014) in healthy young adults.

synapsesocial.com/papers/6abe3592bdd7597321d9a4a5 https://doi.org/10.23751/pn.v22i1-s.9821

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Implication

May necessitate caution interpreting CK-MB in active young adults; leaves open sex- and exercise-specific effects on hsTnI reference values.

Comparison of Creatine Kinase Myocardial Band (CK-MB) and High Sensitive Troponin I (hsTnI) Values Between Athletes and Sedentary People

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Comparison of Creatine Kinase Myocardial Band (CK-MB) and High Sensitive Troponin I (hsTnI) Values Between Athletes and Sedentary People

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

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