Key result
Coronary bifurcation simulations show lateral walls experience low shear stress, predisposing them to atherosclerosis.
Why the study?
Practical difficulties, particularly long model development time, have limited the types and applicability of computational fluid dynamics simulations in numerical modeling of blood flow in coronary artery bifurcations.
A novel fluid-structure interaction simulation framework identifies low endothelial shear stress and low oscillatory shear index at coronary bifurcations as markers for atherosclerosis predilection.
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Supports biomechanical targeting of coronary bifurcations in atherosclerosis research; leaves open prospective validation in patient outcomes.
Blagojević et al. (2014) studied Coronary artery bifurcations. Finite element simulation of fluid-structure interaction was evaluated on Endothelial shear stress distribution and oscillatory shear index. Finite element simulation of fluid-structure interaction in coronary bifurcations revealed lateral walls are exposed to low endothelial shear stress (<1.5), predisposing to atherosclerosis.
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