Key result
Eplerenone alone or with trandolapril improves post-MI LV remodeling and reduces fibrosis in rats.
Why the study?
Adding an aldosterone antagonist to ACE inhibition reduces mortality and morbidity in heart failure, but the effects on ventricular remodeling after MI were investigated.
Does eplerenone alone or in combination with trandolapril improve ventricular remodeling in rats with LV dysfunction after extensive MI?
Does eplerenone alone or in combination with trandolapril improve ventricular remodeling in rats with LV dysfunction after extensive MI?
No takes yet. Share an insight, caveat, or question.
In a rat model of post-MI LV dysfunction, combining eplerenone with an ACE inhibitor provided additive benefits in preventing adverse LV remodeling, fibrosis, and molecular alterations compared to either monotherapy.
Fraccarollo et al. (2003) studied left ventricular dysfunction after extensive myocardial infarction. Eplerenone and trandolapril vs. placebo was evaluated on ventricular remodeling. Eplerenone alone and combined with trandolapril improved LV remodeling, attenuated LVEDP and LVEDV, and reduced fibrosis in rats with LV dysfunction after extensive MI compared with placebo.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: