Why the study?
Does eplerenone, alone or in combination with lisinopril, improve cardiovascular mass, myocardial collagen, and coronary circulation in spontaneously hypertensive rats?
Population
Male, 22-week-old spontaneously hypertensive rats (n=48)
Comparison
Eplerenone, lisinopril, or combination of… vs No treatment (control group)
Design
Preclinical, Randomly divided into 4 groups
Follow-up
12 weeks
Authors
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No immediate clinical implications; extends preclinical data on eplerenone-lisinopril synergy for coronary reserve while leaving human remodeling effects open.
Does eplerenone, alone or in combination with lisinopril, improve cardiovascular mass, myocardial collagen, and coronary circulation in spontaneously hypertensive rats?
In spontaneously hypertensive rats, eplerenone improves coronary and systemic hemodynamics without affecting cardiovascular mass, and shows synergistic effects when combined with lisinopril.
Sušić et al. (2005) studied this question.
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