Key result
Alzheimer's mortality with comorbid hypertension surges ~375% among older US adults from 1999 to 2020.
Why the study?
Temporal trends and demographic disparities in Alzheimer's disease-related mortality among adults aged 65 years and older with comorbid hypertension in the US were not well characterized.
Observational (n=409,112)
Yes
Absolute Event Rate: 69.06% vs 14.51%
Alzheimer's disease-related mortality among older adults with comorbid hypertension in the US increased substantially from 1999 to 2020, disproportionately affecting females and non-Hispanic Black individuals.
Rising AD mortality with hypertension warrants monitoring but should not change practice; leaves open need for prospective studies on modifiable factors.
AIMS: To examine temporal trends and demographic disparities in Alzheimer's disease (AD)-related mortality among adults aged ≥ 65 years with comorbid hypertension in the United States from 1999 to 2020. MATERIALS AND METHODS: We conducted a population-based retrospective analysis using the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) Multiple Cause of Death database. Deaths involving AD (ICD-10 G30) and hypertension (ICD-10 I10-I15) were identified. Age-adjusted mortality rates (AAMRs) were assessed by sex, race/ethnicity, geographic region, urbanization level, and state. Temporal trends were evaluated using Joinpoint regression. RESULTS: Between 1999 and 2020, 409,112 deaths involving AD and hypertension were recorded. The overall AAMR increased from 14.51 per 100,000 in 1999 to 69.06 in 2020, with a decline from 2007 to 2014 followed by an increase through 2020. Females had higher AAMRs than males, and non-Hispanic Black individuals had the highest AAMR among the racial and ethnic groups examined. CONCLUSIONS: AD-related mortality among older adults with comorbid hypertension increased substantially during the study period, with notable demographic and geographic disparities.
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Shahbaz et al. (2026) conducted an observational in Alzheimer's disease with comorbid hypertension (n=409,112). Time period (1999-2020) vs. 1999 (baseline) was evaluated on Age-adjusted mortality rates (AAMRs) per 100,000. Age-adjusted mortality rates for Alzheimer's disease with comorbid hypertension increased from 14.51 per 100,000 in 1999 to 69.06 per 100,000 in 2020 among US adults aged ≥65 years.
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