Key result
Between 1999 and 2020, the age-adjusted mortality rate for ischemic heart disease among US adults with Alzheimer's disease decreased significantly from 10.56 to 4.03 per 100,000 (AAPC -4.74).
Why the study?
IHD and Alzheimer's disease significantly contribute to mortality in the aging population, making understanding mortality trends where these conditions overlap crucial for developing targeted interventions.
Observational (n=171,080)
Effect estimate: AAPC -4.74 (95% CI -4.98 to -4.51)
Absolute Event Rate: 4.03% vs 10.56%
Ischemic heart disease mortality among US adults with Alzheimer's disease declined significantly between 1999 and 2020, though demographic and regional disparities remain.
Should not yet change practice; leaves open whether persistent gender, racial, and geographic disparities are modifiable.
Background: Ischemic heart diseases (IHD) and Alzheimer's Disease (AD) significantly contribute to mortality in aging population. Understanding mortality trends where these conditions overlap is crucial for developing targeted interventions for vulnerable populations. Methods: We analyzed CDC WONDER mortality data from 1999 to 2020 for individuals aged ≥45 years. IHD and AD mortality were identified using ICD-10 codes I20-I25 and G30, respectively. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were analyzed by gender, race, region, place of death and state. Joinpoint regression was used to calculate annual percentage changes (APC) with 95 % confidence intervals (CI). Results: A total of 171,080 deaths were attributed to IHD in individuals with AD from 1999 to 2020. The AAMR decreased from 10.6 in 1999 to 4.1 in 2020, with a significant decline between 2004 and 2014 (APC: -7.73; 95 % CI: -8.42 to -7.24). Females exhibited higher overall AAMR compared to males (Females: 6.8 vs. Males: 6.4). Individuals of Non-Hispanic (NH) White ancestry had the highest AAMR (6.8), followed by those of NH Black (6.5) and Hispanic ancestry (5.9). The West region reported the highest AAMR at 7.9, while the Midwest had the lowest at 6.3. Oklahoma recorded the highest state-level AAMR (10.9), while Utah had the lowest (3.2). Conclusions: IHD mortality in individuals with AD declined significantly, with disparities by gender, race, and geography. These findings underscore the need for tailored public health approaches to address the evolving burden of IHD in AD patients.
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Akhtar et al. (2025) conducted an observational in Ischemic heart disease and Alzheimer's disease (n=171,080). Calendar year vs. 1999 (baseline) was evaluated on Age-adjusted mortality rate (AAMR) per 100,000 (AAPC -4.74, 95% CI -4.98 to -4.51). Between 1999 and 2020, the age-adjusted mortality rate for ischemic heart disease among US adults with Alzheimer's disease decreased significantly from 10.56 to 4.03 per 100,000 (AAPC -4.74).
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