Key result
Extended posterior leaflet augmentation with annuloplasty achieves ~4% 4-year reoperation for advanced atrial functional MR.
Why the study?
Isolated mitral annuloplasty may be inadequate to prevent mitral regurgitation recurrence in atrial functional mitral regurgitation, especially in advanced stages.
Does extended posterior leaflet augmentation combined with mitral annuloplasty prevent recurrent mitral regurgitation in patients with advanced-stage atrial functional mitral regurgitation?
Observational (n=45)
No
Does extended posterior leaflet augmentation combined with mitral annuloplasty prevent recurrent mitral regurgitation in patients with advanced-stage atrial functional mitral regurgitation?
Extended posterior leaflet augmentation combined with mitral annuloplasty provides sufficient coaptation length and excellent freedom from recurrent MR in patients with advanced-stage atrial functional mitral regurgitation.
May support extended augmentation for advanced atrial functional MR; leaves open randomized confirmation of durability and survival benefit.
Atrial functional mitral regurgitation (AFMR) is caused by mitral annular dilatation and "hamstringing" of the posterior leaflet associated with permanent atrial fibrillation (AF) -induced severe left atrial dilation.Isolated mitral annuloplasty (MAP) may be inadequate to prevent mitral regurgitation (MR) recurrence, especially in advanced stages.To manage AFMR, we combined extended posterior leaflet augmentation with MAP to obtain an effective coaptation length.We investigated 45 patients with permanent AF and AFMR, 20 (44.4%) of whom were New York Heart Association class III or IV.Of the 45 patients, 26 (57.8%) were in advanced stage (complex of severe left atrial and left ventricular enlargement, left ventricular dysfunction, and severe MR grade) and underwent MAP with extended posterior leaflet augmentation ; 19 (42.2%) were in early stage and underwent MAP without leaflet augmentation.The coaptation length in the midsystolic parasternal long-axis view was calculated using echocardiography and compared in both groups.Patients with advanced stage demonstrated a larger mitral annular diameter.Except for two patients, MR was rated mild or lower up to 4 years postoperatively.Follow-up echocardiography revealed sufficient coaptation length in both groups (9.0 and 7.0 mm in the advanced-stage and early stage groups, respectively, throughout the 3-year follow-up period) .The overall 4-year freedom from cardiacrelated mortality was 90.4%.Recurrence of MR ≥ mild was 5.0%, and the 4-year reoperation rate was 2.6% (advanced stage, 4.2% ; early stage, 0% ; p =0.323) .Extended posterior leaflet augmentation was effective for patients with advanced-stage AFMR, yielding sufficient coaptation length, excellent freedom from recurrent MR, and survival comparable to patients with early stage AFMR.
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Kadowaki et al. (2026) conducted an observational in Atrial functional mitral regurgitation with permanent atrial fibrillation (n=45). Extended posterior leaflet augmentation with mitral annuloplasty vs. Mitral annuloplasty alone was evaluated on Freedom from ≥ moderate mitral regurgitation. Extended posterior leaflet augmentation with mitral annuloplasty for advanced-stage atrial functional mitral regurgitation yielded sufficient coaptation length and excellent freedom from recurrent MR, with a 4-year reoperation rate of 4.2% comparable to 0% in early-stage patients.
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