Key result
Anterior mitral leaflet augmentation using an untreated autologous pericardial patch resulted in 100% freedom from moderate to severe mitral regurgitation at 1.1-year follow-up.
Why the study?
Patch augmentation of the anterior mitral leaflet is used to treat functional mitral regurgitation, but the choice of patch material remains a matter of debate.
Does augmentation of the anterior mitral leaflet with an untreated autologous pericardial patch improve mitral regurgitation in patients with functional mitral regurgitation?
Observational (n=30)
No
Does augmentation of the anterior mitral leaflet with an untreated autologous pericardial patch improve mitral regurgitation in patients with functional mitral regurgitation?
Augmentation of the anterior mitral leaflet with an untreated autologous pericardial patch effectively eliminates moderate-to-severe functional mitral regurgitation at 1-year follow-up.
May support anterior leaflet repair techniques; hypothesis-generating and requires prospective validation before adoption.
Background: Patch augmentation of the anterior mitral leaflet (AAML) is being used to treat functional mitral regurgitation (fMR) with the choice of patch material, however, still being a matter of debate. Therefore, the aim of this study was to determine the early‐ and 1‐year results of AAML for fMR. Methods: Between 2020 and 2022, 30 patients underwent AAML for Carpentier Type IIIb fMR using an untreated autologous pericardial patch in our institution. The mean age of the patients was 61.3 ± 19.3 years, and 16 patients (53.3%) were male. Early‐ and 1‐year results of mitral valve repair were assessed via clinical follow‐up including echocardiographic examination. Results: Twenty patients (66.7%) were operated on through a right mini‐thoracotomy and 10 patients (33.3%) via a median sternotomy, with 19 patients (63.3%) receiving a concomitant procedure. Three patients (10%) required postoperative mechanical circulatory support (MCS), with one of those patients (3.3%) deceasing due to multiple organ failure. Postoperative echocardiography showed that all patients (100%) had either no or mild MR. Freedom from moderate to severe MR was 100% ( n = 29) at discharge as well as after a 1.1 ± 0.17‐year follow‐up ( n = 26; with an additional three patients (10%) that deceased during the first postoperative year due to non–valve‐related causes). No patient required mitral valve‐related reoperation or intervention. Conclusions: AAML using an untreated autologous pericardial patch is a safe and reproducible surgical technique for fMR, with promising early results up to a 1‐year follow‐up. Further follow‐up is warranted to determine long‐term results especially with regard to the durability of mitral valve repair.
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Memedi et al. (2025) conducted an observational in Functional mitral regurgitation (n=30). Anterior mitral leaflet augmentation with an untreated autologous pericardial patch was evaluated on Freedom from moderate to severe mitral regurgitation at 1.1-year follow-up. Anterior mitral leaflet augmentation using an untreated autologous pericardial patch resulted in 100% freedom from moderate to severe mitral regurgitation at 1.1-year follow-up.
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