Key result
Beta blockade suppresses swallowing-induced PACs, while catecholamines trigger them via sympathetic reflex.
Why the study?
Swallowing-induced arrhythmia is a rare clinical entity with unclear mechanisms, and few reports have proposed a sympathetic reflex as responsible.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Challenges presumed vagal mechanism in deglutition arrhythmia; leaves open sympathetic mediation for prospective validation.
Deglutition tachyarrhythmia, first reported in 1926 by Sakai and Mori, is a rare clinical entity. Vagal reflex has been supposed to be responsible for the induction of the arrhythmia. We have recently studied a patient with swallowing-induced premature atrial contractions. Atropine sulfate and catecholamine infusion increased the frequency of the arrhythmia, while beta blockade suppressed it. It is suggested that the mechanism of the swallowing-induced arrhythmia might be related to a sympathetic reflex. As far as we know, there have been few reports in which the sympathetic reflex was proposed to be responsible for the arrhythmia.
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Inoue et al. (1988) conducted a case report in Swallowing-induced premature atrial contractions (n=1). Atropine sulfate, catecholamine infusion, and beta blockade was evaluated on Frequency of arrhythmia. Atropine sulfate and catecholamine infusion increased the frequency of swallowing-induced premature atrial contractions, while beta blockade suppressed it, suggesting a sympathetic reflex mechanism.
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