Persistent Immune Activation and Chronic Inflammation: Unraveling Their Impact on Anemia in HIV Infection

Persistent immune activation and chronic inflammation represent pivotal facets of Human Immunodeficiency Virus (HIV) infection, profoundly influencing disease progression and complications. This abstract synthesizes current knowledge to unravel the intricate interplay between persistent immune activation, chronic inflammation, and their consequential impact on the development and exacerbation of anemia among individuals living with HIV. Persistent immune activation and chronic inflammation are recognized hallmarks of HIV infection, contributing significantly to disease pathogenesis and complications. This paper aims to elucidate their intricate roles in perturbing erythropoiesis, leading to anemia, thus highlighting the pathophysiological mechanisms and clinical implications within the context of HIV. Anemia, emerging as a consequence of persistent immune activation and chronic inflammation in HIV, bears significant clinical implications. Its association with disease progression, treatment responses, and prognostic implications underscores its criticality in the comprehensive care of HIV-infected populations. Persistent immune activation and chronic inflammation intricately contribute to the pathogenesis of anemia in HIV infection. Understanding their multifaceted roles in disrupting erythropoiesis holds promise for developing targeted interventions and refining management strategies to alleviate anemia burden among individuals living with HIV.