Key result
External iliac systolic pressure strongly correlates with superior mesenteric artery pressure in acute aortic dissection.
Why the study?
Visceral malperfusion in acute aortic dissection is diagnosed late due to reliance on end-organ failure signs, which may be clinically obscure.
Does external iliac artery systolic pressure correlate with superior mesenteric artery systolic pressure in patients with acute aortic dissection where both vessels are supplied exclusively by the true lumen?
Cohort (n=76)
No
Does external iliac artery systolic pressure correlate with superior mesenteric artery systolic pressure in patients with acute aortic dissection where both vessels are supplied exclusively by the true lumen?
In acute aortic dissection with exclusive true lumen supply to the SMA and iliac arteries, loss of the femoral pulse strongly correlates with decreased SMA perfusion pressure, serving as an early clinical indicator of visceral malperfusion.
Answers are grounded in this paper and cite their sources.
May support femoral pulse loss as SMA malperfusion marker in true-lumen acute aortic dissection; leaves open prospective validation before practice change.
Background Visceral malperfusion is a serious complication of acute aortic dissection. Currently, diagnosis relies on signs of end-organ failure, which may be clinically obscure and delay crucial treatment. Objective The aim was to investigate external iliac (IA) and superior mesenteric artery (SMA) pressures in cases where both vessels originate exclusively from the true lumen to develop and validate a novel early indicator of visceral malperfusion. Methods Endovascular pressure measurements from 488 patients with acute aortic dissection were analyzed. Exclusion criteria included static obstruction of the branch vessel or substantial re-entry tear below the SMA origin. Results In acute type A aortic dissection, 69 out of 244 (28.3%) patients had at least 1 common IA and the SMA with exclusive true lumen perfusion. Among all patients with acute type A aortic dissection, 41 (16.8%) patients with 49 external IA pressure measurements met inclusion criteria. Pressures in right external IA (n = 27) and left external IA (n = 22) correlated significantly with SMA perfusion pressure ( r 2 = 0.86 [95% CI, 0.71-0.93; P = 1.03 E-08 ] and r 2 = 0.86 [95% CI, 0.69-0.94; P = 2.85 E-07 ], respectively). In settings of acute type B aortic dissection, 81 out of 244 (33.2%) patients had at least 1 common IA and the SMA with exclusive true lumen perfusion. Among all patients with acute type B aortic dissection, 35 (14.3%) patients with 44 external IA pressure measurements met inclusion criteria. The right external IA (n = 24) and left external IA (n = 20) pressures correlated significantly with SMA perfusion pressure ( r 2 = 0.92 [95% CI, 0.83-0.97; P = 1. 59E-10 ] and r 2 = 0.87 [95% CI, 0.70-0.95; P = 6.12 E-07 ], respectively). Conclusions In acute aortic dissection where the SMA and a common IA are supplied exclusively by the true lumen, external IA systolic pressures correlate significantly with SMA systolic pressures. In this group, therefore, clinical loss of the femoral pulse likely indicates significantly decreased SMA pressures, raising concern for visceral malperfusion, possibly before visceral enzymes can respond. We believe that computed tomography reports should highlight this anatomical finding to alert the clinical team monitoring the patient.
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Pinsky et al. (2024) conducted a cohort in Acute aortic dissection with vulnerable anatomy (n=76). External iliac artery systolic pressure was evaluated on Correlation between right external iliac artery and superior mesenteric artery systolic pressures in acute type A aortic dissection (r2 = 0.86, 95% CI 0.71-0.93, p=1.03 E-08). In acute aortic dissection with exclusive true lumen supply, external iliac systolic pressures strongly correlated with superior mesenteric artery systolic pressures (r2=0.86-0.92).
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