What is the clinical evidence from this study?

Study design: Case Report. Population: Severe rhabdomyolysis (n=1). Intervention: Rosuvastatin. Primary outcome: Creatine kinase levels and clinical recovery.

What does this research mean for the field?

Severe statin-associated rhabdomyolysis can manifest with marked biochemical injury and minimal muscular symptoms even after long-term rosuvastatin exposure. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe a case of severe, biochemically profound rhabdomyolysis with atypical, minimal muscular symptoms following prolonged rosuvastatin therapy.

October 4, 2026CureusOpen Access

Severe Rhabdomyolysis With Minimal Muscular Symptoms After Long-Term Rosuvastatin Use: A Case Report and Brief Literature Review

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Key result

Long-term rosuvastatin linked to severe rhabdomyolysis with CK peaking at ~39,000 U/L.

Why the study?

Severe rhabdomyolysis may present with limited muscular symptoms despite substantial biochemical injury during long-term statin exposure.

Comparison

Long-term rosuvastatin exposure

Design

Case report

Authors

ABAlireza Izadian Bidgoli AUAlberto Gomez Usatorres HUHellen Ailette Gomez Usatorres

Discussion

Member takes

Implication

Severe rhabdomyolysis can occur with minimal muscular symptoms even after long-term statin exposure, highlighting the discrepancy between biochemical severity and clinical presentation.

Key Points

To describe a case of severe, biochemically profound rhabdomyolysis with atypical, minimal muscular symptoms following prolonged rosuvastatin therapy.
Clinical and diagnostic evaluation of a 65-year-old male with chronic kidney disease, type 2 diabetes, and bilateral below-knee amputations presenting after over 10 years of rosuvastatin use.
Serial biochemical monitoring of creatine kinase, renal parameters, autoimmune myositis panels, and muscle MRI following statin withdrawal and supportive hemodialysis.
Creatine kinase levels rose from an admission value of 23,107 U/L to a peak of 38,747 U/L alongside severe azotemia (creatinine 7.80 mg/dL) that necessitated hemodialysis, despite minimal muscle-specific complaints.
Discontinuation of rosuvastatin and supportive hemodialysis resulted in clinical resolution of weakness and encephalopathy, with creatine kinase declining to 1,003 U/L by hospital discharge.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 65-year-old man with advanced chronic kidney disease, type 2 diabetes, and peripheral arterial disease who developed severe rhabdomyolysis after long-term rosuvastatin use.

Exposure

Rosuvastatin for more than 10 years

Outcome

Severe rhabdomyolysis (creatine kinase elevation and acute kidney injury)safety

Severe rhabdomyolysis can occur with minimal muscular symptoms even after long-term statin exposure, highlighting the discrepancy between biochemical severity and clinical presentation.

Limitations

Did not establish causality
Did not exclude an autoimmune mechanism

Cite This Study

Bidgoli et al. (2026) conducted a case report in Severe rhabdomyolysis (n=1). Rosuvastatin was evaluated on Creatine kinase levels and clinical recovery. Long-term rosuvastatin exposure in a 65-year-old man was associated with severe rhabdomyolysis (creatine kinase peaking at 38,747 U/L) despite minimal muscular symptoms.

synapsesocial.com/papers/6ac1ec15e428693a5716debd https://doi.org/10.7759/cureus.117283

Topics

PCSK9 inhibitors

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Implication

Severe rhabdomyolysis can occur with minimal muscular symptoms even after long-term statin exposure, highlighting the discrepancy between biochemical severity and clinical presentation.

Severe Rhabdomyolysis With Minimal Muscular Symptoms After Long-Term Rosuvastatin Use: A Case Report and Brief Literature Review

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Topics

Severe Rhabdomyolysis With Minimal Muscular Symptoms After Long-Term Rosuvastatin Use: A Case Report and Brief Literature Review

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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