Electrochemical sensor based on Ag-metal organic framework/carbon black nanocomposite for the selective detection of Ticagrelor

Ticagrelor (TIC) is an effective drug in inhibiting platelets and is useful for preventing cardiovascular death, ischaemic stroke, or myocardial infarction. In this regard, a novel electrochemical sensor was reported based on a glassy carbon electrode modified with a carbon black/Ag-metal organic framework nanocomposite (GCE/CB/Ag-MOF) for selective TIC detection. To the best of our knowledge, the electrochemical application of a CB/Ag-MOF composite for TIC determination has not previously been reported. The proposed electrode was prepared by creating a conductive platform using Ag-MOF-decorated CB, forming a CB/Ag-MOF composite. Electrochemical tests were performed on the modified GCE using differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). The modified GCE showed a low limit of detection (LOD) of 0.0033 nM, a linear response over 0.01–2500 nM, and excellent selectivity, reproducibility, repeatability, and stability. A successful application in a serum sample yielded a recovery of 99.5–101.2% and a relative standard deviation (RSD) of less than 2.8%.