Key result
First HF discharge in 2003 linked to ~2-fold higher 1-year beta-blocker adherence vs 1995.
Why the study?
The use of evidence-based medications in heart failure patients has increased, but whether adherence to these medications has also improved over time was unclear.
Cohort (n=8,805)
Odds Ratio: 2.04 (95% CI 1.21–3.44)
Absolute Event Rate: 75% vs 54%
p-value: p=<0.001
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Adherence to HF therapies improved over a decade; leaves open causal drivers and outcome impact in observational data.
Lamb et al. (2009) conducted a cohort in heart failure (n=8,805). Hospital discharge in 2002/2003 vs. Hospital discharge in 1994/1995 was evaluated on Optimal adherence (≥80%) to beta-blockers at 1 year (OR 2.04, 95% CI 1.21 to 3.44, p=<0.001). Patients discharged after a first heart failure hospitalization in 2003 were significantly more likely to exhibit optimal 1-year adherence to beta-blockers (OR 2.04) and ACEI/ARBs (OR 1.65) than in 1994/1995.