Potential Anti-Microbial, Anti-Inflammatory and Anti-Oxidant Activities of Haplophyllum tuberculatum Growing in Libya

Ethanolic extract of the aerial parts of Haplophyllum tuberculatum demonstrated an efficient anti-fungal activity against Aspergillus fumigates, Geotricum candidum and Syncephalastrum racemosum with (MIC 0.49, 0.12 and 1.95 μg/ml). It also presented 75% potency as antibacterial agent on Staphylococcus aureus and Escherichia coli (MIC 1.95 and 15.63 μg/ml). Volatile oil of the aerial parts demonstrated significant antibacterial effect against Enterococcus faecalis and Lactobacillus acidophilus (MIC 1.95 and 0.98 μg/ml). The essential oils from aerial parts and flowers exhibited a remarkable acute anti-inflammatory activity against carrageenan induced oedema in rats 9.52 and 8.56 which were found to be comparable to the standard drug at the selected dose. The ethanolic extract of the aerial parts exhibited significance anti-oxidant activity (98%) as compared to vitamin E.