Key result
Standard vectorcardiography yields ~46% false-positive MI rates in aortic valve disease, mitigated by transverse voltage criteria.
Why the study?
Vectorcardiographic criteria for myocardial infarction diagnosis may yield false positives in patients with left ventricular hypertrophy due to aortic valve disease, requiring evaluation of diagnostic accuracy.
Population
77 patients with significant aortic valve disease and normal coronary arteriograms
Comparison
VCG criteria for anterior and inferior myocardial infarction with and without maximal transverse plane magnitude >1.9 mV rule
Design
Cross-sectional analysis of vectorcardiograms
Authors
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Caution against unadjusted vectorcardiographic MI criteria in aortic valve disease; leaves open prospective validation of magnitude thresholds.
Cross-Sectional (n=659)
p-value: p=<0.01
Phillips et al. (1976) conducted a cross-sectional in Myocardial infarction in the presence of left ventricular hypertrophy (n=659). Vectorcardiographic (VCG) criteria vs. Normal volunteers and patients with normal hearts was evaluated on False positive diagnosis of anterior and/or inferior myocardial infarction (p=<0.01). Vectorcardiographic criteria yielded a 46% false-positive rate for myocardial infarction in aortic valve disease; deferring diagnosis when transverse magnitude >1.9 mV improved AMI accuracy (P<0.05).
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