Key result
Recent ischemic stroke is linked to ~94% higher total plasma homocysteine levels versus controls.
Why the study?
Elevated homocysteine is an independent risk factor for ischemic stroke, and MTHFR C677T mutation is a common cause of hyperhomocysteinaemia.
Are elevated homocysteine levels and MTHFR C677T mutations associated with ischemic stroke?
Case-Control (n=82)
Are elevated homocysteine levels and MTHFR C677T mutations associated with ischemic stroke?
Absolute Event Rate: 18.94% vs 9.77%
p-value: p=<0.001
Elevated homocysteine levels and MTHFR C677T mutations are significantly associated with recent ischemic stroke.
May inform genetic risk assessment in stroke; extends observational data but leaves causal and therapeutic questions open.
Elevated homocysteine level in blood is known as independent risk factor for ischemic stroke. One of the most common causes of hyperhomocysteinaemia is methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation. 43 patients with last month ischemic stroke incident were investigated and compared with 39 healthy (controls). Total plasma homocysteine levels was significantly high in cases versus controls (18.94±1.49 and 9.77±0.86 (μmol/L), p<0.001). Mutations frequency concurs with available investigations results. Tendency of homocysteine level elevation connected with heterozygous and homozygous mutation of MTHFR gene was found.
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A. A. Hovsepyan (2006) conducted a case-control in Ischemic stroke (n=82). Ischemic stroke vs. Healthy controls was evaluated on Total plasma homocysteine levels (μmol/L) (p=<0.001). Total plasma homocysteine levels were significantly higher in patients with a recent ischemic stroke compared to healthy controls (18.94 vs 9.77 μmol/L, p<0.001).
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