Bolalarda ogʻir qoʻshma bosh miya jarohatlarining yurak urish chastotasi sirkadian ritmi va sirkadian indeksga ta'siri

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Severe combined traumatic brain injury (n=20). Intervention: Intensified stress-protective therapy vs. Standard stress-protective therapy (historical cohort). Primary outcome: Mesor of the circadian heart rate rhythm.

Q: What does this research mean for the field?

In children over 7 years old with severe combined traumatic brain injury, patients with a lower Glasgow Coma Scale score of 7 maintain higher compensatory cardiac output levels (0.7) than those with a score of 9 (0.4) despite a consistently reduced circadian index. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Khura Mukhitdinova; Gulchekhra Khamraeva; Akmal Shomurodov; Gulkhan Alauatdinova; Феруза Сабирова; Khura Mukhitdinova; Gulchekhra Khamraeva; Akmal Shomurodov; Gulkhan Alauatdinova; Феруза Сабирова; Xura Muxitdinova; Gulchexra Xamraeva; Akmal Shomurodov; Gulxan Alauatdinova; Феруза Сабирова

doi:10.47689/2181-3663-vol5-iss3-pp1-10

June 5, 2026Профилактическая медицина и здоровьеOpen Access

Bolalarda ogʻir qoʻshma bosh miya jarohatlarining yurak urish chastotasi sirkadian ritmi va sirkadian indeksga ta'siri

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Why the study?

The impact of severe combined traumatic brain injury on the circadian rhythm of heart rate and circadian index in children over 7 years was unclear.

Does intensified stress-limiting therapy improve the circadian rhythm of heart rate and circadian index in children with severe combined traumatic brain injury?

Study Design

Type

Cohort (n=20)

Multicenter

No

Structured PICO

Does intensified stress-limiting therapy improve the circadian rhythm of heart rate and circadian index in children with severe combined traumatic brain injury?

P

Population

20 children aged 7.1 to 18 years with severe combined traumatic brain injury treated in a pediatric intensive care unit, compared across two cohorts receiving different intensities of stress-protective therapy.

I

Intervention

Intensified stress-limiting therapy including significantly greater use of analgesics, sedatives, and muscle relaxants (Group 2, n=10, treated 2023-2024).

C

Comparator

Standard or less intensive stress-limiting therapy (Group 1, n=10, treated 2018-2022).

O

Outcome

Circadian rhythm of heart rate (mesor, acrophase, bathyphase, amplitude) and circadian index (CI).surrogate

Limitations

Small sample size
Use of a historical control group

Implication

Severe combined traumatic brain injury in children leads to a persistently reduced circadian index of heart rate regardless of the intensity of stress-protective therapy, indicating a potential risk for myocardial dysfunction.

Abstract

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Discussion

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Cite This Study

Mukhitdinova et al. (2026) conducted a cohort in Severe combined traumatic brain injury (n=20). Intensified stress-protective therapy vs. Standard stress-protective therapy (historical cohort) was evaluated on Mesor of the circadian heart rate rhythm.

synapsesocial.com/papers/6ac2fd227180a622ddd4df7d https://doi.org/10.47689/2181-3663-vol5-iss3-pp1-10

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Bolalarda ogʻir qoʻshma bosh miya jarohatlarining yurak urish chastotasi sirkadian ritmi va sirkadian indeksga ta'siri

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Bolalarda ogʻir qoʻshma bosh miya jarohatlarining yurak urish chastotasi sirkadian ritmi va sirkadian indeksga ta'siri

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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