Key result
Nitroglycerin patch boosts ABI ~23% following sciatic nerve block in diabetic foot syndrome.
Why the study?
The effect of incorporating temgicoluril into standard treatment for Q-wave myocardial infarction on nitric oxide synthase activity and serum cortisol levels was unclear.
Does the addition of a topical nitroglycerin patch to a single peripheral nerve block of the sciatic nerve improve macro- and microcirculation and clinical parameters in elderly patients with diabetic foot syndrome?
RCT (n=40)
No
Does the addition of a topical nitroglycerin patch to a single peripheral nerve block of the sciatic nerve improve macro- and microcirculation and clinical parameters in elderly patients with diabetic foot syndrome?
May improve circulation in diabetic foot after nerve block; leaves open need for RCTs on clinical outcomes.
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Hummetova et al. (2026) conducted an RCT in Diabetic foot syndrome (n=40). Single peripheral nerve block of the sciatic nerve with nitroglycerin patch vs. Single peripheral nerve block of the sciatic nerve without nitroglycerin patch was evaluated on Ankle-Brachial Index (ABI) at postoperative day 15 (p=<0.050). The application of a nitroglycerin patch following a single peripheral nerve block of the sciatic nerve significantly improved macro- and microcirculation parameters in elderly patients with diabetic foot syndrome.
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