Key result
Temgicoluril linked to ~17% lower eNOS activity and higher cortisol when added to standard therapy.
Why the study?
Non-Q-wave myocardial infarction is accompanied by changes in nitric oxide metabolism and the stress response, and the biochemical effects of adding temgicoluril to standard treatment required clarification.
Does adding temgicoluril to standard therapy and rehabilitation alter nitric oxide synthase isoform activity and plasma nitrite, peroxynitrite, and cortisol concentrations in patients with non-Q-wave myocardial infarction?
Observational (n=40)
None (non-randomized, groups defined by treatment received in routine care)
No
Does adding temgicoluril to standard therapy and rehabilitation alter nitric oxide synthase isoform activity and plasma nitrite, peroxynitrite, and cortisol concentrations in patients with non-Q-wave myocardial infarction?
In patients with non-Q-wave myocardial infarction, adding the anxiolytic temgicoluril to standard post-PCI therapy and rehabilitation was associated with lower post-treatment nitrite and endothelial NOS activity and higher cortisol levels compared to standard therapy alone, showing no evidence of superior endothelial recovery or clinical advantage.
Introduction. Non-Q-wave myocardial infarction is accompanied by changes in nitric oxide metabolism and the stress response. The biochemical effects of adding temgicoluril to standard treatment require clarification.Aim. To assess changes in nitric oxide synthase isoform activity, nitrite, peroxynitrite and cortisol concentrations during standard therapy with or without temgicoluril.Materials and methods. The prospective study included 40 patients (mean age 62.9±11.7 years, mean±standard deviation), divided into two groups of 20. Both groups received standard therapy and multidisciplinary rehabilitation. Group 2 additionally received temgicoluril, 500 mg three times daily for one month. Blood biochemical parameters were assessed before and after treatment and compared with those of 20 control participants.Results. Biochemical values are means ± standard errors. Before treatment, both patient groups had lower endothelial enzyme activity and higher neuronal enzyme activity, nitrite, peroxynitrite and cortisol concentrations than controls. Baseline values did not differ significantly between treatment groups. Endothelial nitric oxide synthase activity increased in both groups during treatment, while nitrite, peroxynitrite and cortisol concentrations decreased. After treatment, nitrite concentrations were 1.25±0.04 nmol/L in group 1 and 1.00±0.04 nmol/L in group 2. Endothelial enzyme activity was lower in group 2 than in group 1 (0.34±0.005 versus 0.41±0.001 µmol/min per g protein). Inducible and neuronal enzyme activities were higher in group 2, whereas peroxynitrite concentrations did not differ significantly between groups. Cortisol decreased from 252.2±9.2 to 67.2±1.2 nmol/L in group 1 and from 278.5±10.8 to 126.2±3.4 nmol/L in group 2. Endothelial enzyme activity remained below the control value in both groups.Conclusions. Both regimens were associated with changes in nitric oxide metabolism and a decline in cortisol. Temgicoluril use was associated with lower post-treatment nitrite but higher cortisol concentrations than standard therapy alone. These biochemical differences do not establish superior endothelial recovery or a clinical advantage of the additional treatment.
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Honchar et al. (2026) conducted an observational in Acute non-Q-wave myocardial infarction (n=40). Temgicoluril added to standard therapy and multidisciplinary rehabilitation vs. Standard therapy and multidisciplinary rehabilitation alone was evaluated on Post-treatment endothelial nitric oxide synthase (eNOS) activity (µmol/min per g protein) (p=0.00000007). Temgicoluril added to standard therapy resulted in lower post-treatment eNOS activity (0.34 vs 0.41 µmol/min/g, p=0.00000007) and higher cortisol (126.2 vs 67.2 nmol/L) than standard therapy alone.
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