Key result
Periodontitis is linked to ~0.85 m/s higher PWV compared to controls.
Why the study?
Patients with periodontitis have a higher risk of cardiovascular diseases, but the causal relationship and impact on arterial stiffness remain unclear.
Population
Patients with periodontitis and non-periodontal diseased controls from 10 clinical studies
Comparison
Patients with periodontitis versus non-periodontal diseased subjects
Design
Systematic review and meta-analysis of clinical studies using pulse wave velocity
Authors
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Periodontitis associates with higher arterial stiffness; supports CVD-oral health link but leaves treatment effects open for RCTs.
Meta-Analysis
Mean Difference: 0.85 (95% CI 0.53–1.16)
p-value: p=<0.00001
Schmitt et al. (2015) conducted a meta-analysis in Periodontitis. Periodontitis vs. Controls (non-periodontal diseased subjects) was evaluated on Arterial stiffness assessed by pulse wave velocity (PWV) (MD 0.85 m/s, 95% CI 0.53-1.16, p=<0.00001). Patients with periodontitis had significantly increased arterial stiffness compared to controls (PWV mean difference 0.85 m/s; 95% CI 0.53-1.16; p<0.00001).
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