Key result
Chronic renal failure linked to nocturnal BP peaks and reduced circadian amplitude vs essential hypertension.
Why the study?
The circadian rhythm of blood pressure is altered in many conditions with autonomic nervous system impairment, and it is unclear how it is affected in chronic renal failure with hypertension.
Population
30 non-hemodialysis hypertensive chronic renal failure patients and 30 mild-to-moderate essential hypertension patients
Comparison
Chronic renal failure hypertension vs essential hypertension
Design
Case-control study with standardized chronobiological statistical analysis
Authors
Loading...
May warrant timed BP assessment in renal failure; leaves open whether chronotherapy improves outcomes.
Case-Control (n=60)
Portaluppi et al. (1990) conducted a case-control in Hypertension with chronic renal failure (n=60). Chronic renal failure vs. Uncomplicated mild-to-moderate essential hypertension was evaluated on Circadian rhythm of blood pressure and heart rate. Chronic renal failure shifted blood pressure acrophases to 11 p.m.-midnight (vs 2-3 p.m. in essential hypertension) and significantly lowered mean circadian amplitudes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: