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Release of intracellular pathogens from host cells is frequently performed by forcing the cells through hypodermic needles attached to a syringe ("syringing"). This can result in needle sticks and infectious aerosols. We describe a reusable, economical host cell lysis device assembled from chromatography components for needle-free and aerosol-minimized manual cell disruption.
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Seeber et al. (2026) studied this question.
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