Key result
Aortic balloon desendothelization induces platelet-rich arterial thrombosis in 80% of rabbits vs. controls.
Why the study?
Aortic desendothelization without a high cholesterol diet as a method to induce arterial atherosclerosis and thrombosis in rabbits had not been tested as a less expensive alternative to existing models.
Comparison
Balloon desendothelization vs no intervention
Design
Experimental animal study
Follow-up
4 months
Authors
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May reduce costs of rabbit thrombosis models; leaves open translation to human cardiovascular research.
Absolute Event Rate: 80% vs 0%
p-value: p=< 0.01
Picon et al. (1997) studied Arterial atherosclerosis and thrombosis (n=19). Aortic balloon desendothelization vs. No intervention was evaluated on Platelet-rich arterial thrombosis (p=< 0.01). Aortic balloon desendothelization without dietary manipulation induced platelet-rich arterial thrombosis in 80% of rabbits compared to 0% in controls (P < 0.01).
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