Key result
Maternal diabetes induces heterotaxy syndrome in ~36% of fetuses in diabetic mice.
Why the study?
Maternal diabetes mellitus in NOD mice leads to a high incidence of visceroatrial heterotaxy syndrome, but detailed analysis of atrial situs subtypes was lacking.
Comparison
fetuses from dams before onset of diabetes mellitus vs fetuses from dams with overt diabetes mellitus before day 8 of pregnancy
Design
Preclinical study
Authors
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Does not yet alter clinical practice; extends NOD mouse evidence on diabetes-induced heterotaxy but requires human confirmation.
Maternal diabetes in the NOD mouse model strongly influences the development of visceroatrial heterotaxy syndrome, particularly right isomerism.
Morishima et al. (1991) studied Visceroatrial heterotaxy syndrome (n=829). Maternal diabetes mellitus vs. Dams before the onset of diabetes mellitus was evaluated on Visceroatrial heterotaxy syndrome. Maternal diabetes mellitus in NOD mice resulted in a 36.1% incidence of heterotaxy syndrome in fetuses, compared to rare occurrences in fetuses from non-diabetic dams.
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