What is the clinical evidence from this study?

Study design: Observational. Population: Deranged laterality and congenital cardiac anomalies (n=275). Intervention: Atrial isomerism vs. Usual or mirror-image arrangement of atrial appendages. Primary outcome: Presence of cardiac defects.

August 1, 1992CirculationOpen Access

Abnormal laterality and congenital cardiac anomalies. Relations of visceral and cardiac morphologies in the iv/iv mouse.

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Key result

Atrial isomerism was universally associated with cardiac lesions (100%), whereas only 3.1% of mice with usual or mirror-image atrial arrangement had cardiac defects.

Population

275 iv/iv mice

Design

Preclinical

Authors

JSJeong‐Wook SeoKorea Atomic Energy Research Institute NBNigel A. BrownSt George's, University of London SHSiew Yen HoAdult Congenital Heart Disease

Discussion

Member takes

Implication

Atrial appendage morphology may better predict cardiac defects in laterality disorders; leaves open translation to human heterotaxy risk stratification.

Study Design

Type

Observational (n=275)

Structured PICO

Population

275 iv/iv mice evaluated for the relations of cardiac defects with atrial, venous, and other visceral morphologies.

Exposure

Morphological examination of the heart and other organs to determine the arrangement of atrial appendages and its relation to cardiac defects

Outcome

Arrangement of atrial appendages and its relation to cardiac defects, venous abnormalities, and spleen abnormalitiessurrogate

Main Result

Absolute Event Rate: 100% vs 3.1%

The morphology of atrial appendages is a more consistent predictor of cardiac abnormalities than the arrangement of other organs or systemic venous connections in the iv/iv mouse model of abnormal laterality.

Cite This Study

Seo et al. (1992) conducted an observational in Deranged laterality and congenital cardiac anomalies (n=275). Atrial isomerism vs. Usual or mirror-image arrangement of atrial appendages was evaluated on Presence of cardiac defects. Atrial isomerism was universally associated with cardiac lesions (100%), whereas only 3.1% of mice with usual or mirror-image atrial arrangement had cardiac defects.

synapsesocial.com/papers/6a9797f69f0d7a8a1afac282 https://doi.org/10.1161/01.cir.86.2.642

Topics

Congenital heart disease adults

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August 1, 1992CirculationOpen Access

Abnormal laterality and congenital cardiac anomalies. Relations of visceral and cardiac morphologies in the iv/iv mouse.

View Full Paper

Ask AI

Bookmark

Key result

Atrial isomerism was universally associated with cardiac lesions (100%), whereas only 3.1% of mice with usual or mirror-image atrial arrangement had cardiac defects.

Population

275 iv/iv mice

Design

Preclinical

Authors

JSJeong‐Wook SeoKorea Atomic Energy Research Institute NBNigel A. BrownSt George's, University of London SHSiew Yen HoAdult Congenital Heart Disease

Discussion

Member takes

Implication

Atrial appendage morphology may better predict cardiac defects in laterality disorders; leaves open translation to human heterotaxy risk stratification.

Study Design

Type

Observational (n=275)

Structured PICO

Population

275 iv/iv mice evaluated for the relations of cardiac defects with atrial, venous, and other visceral morphologies.

Exposure

Morphological examination of the heart and other organs to determine the arrangement of atrial appendages and its relation to cardiac defects

Outcome

Arrangement of atrial appendages and its relation to cardiac defects, venous abnormalities, and spleen abnormalitiessurrogate

Main Result

Absolute Event Rate: 100% vs 3.1%

Cite This Study

synapsesocial.com/papers/6a9797f69f0d7a8a1afac282 https://doi.org/10.1161/01.cir.86.2.642

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Congenital heart disease adults

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