Key result
High soluble CD40L links to endothelial activation after peripheral angioplasty but not 6-month restenosis.
Why the study?
The associations of circulating oncostatin-M and soluble CD40 ligand with fibrinogen, soluble cell adhesion molecules, restenosis, and platelet activation in peripheral arterial occlusive disease were unclear.
Population
71 patients with peripheral arterial occlusive disease undergoing peripheral angioplasty
Comparison
Patients with high versus low soluble CD40L and detectable versus undetectable OSM
Design
Observational study with serial immunological measurements
Follow-up
6 months
Authors
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OSM and CD40L associations with fibrinogen are hypothesis-generating; leaves open causal roles in thrombosis pending prospective studies.
Observational (n=71)
p-value: p=<0.01
Tsakiris et al. (2000) conducted an observational in Peripheral arterial occlusive disease (n=71). High soluble CD40 ligand (CD40L) and circulating oncostatin-M (OSM) vs. Low or undetectable levels was evaluated on Restenosis within 6 months (>50% reduction of the lumen) and endothelial activation markers (p=<0.01). High soluble CD40L levels in patients undergoing peripheral angioplasty were associated with significantly higher soluble VCAM-1 (P<0.01) and thrombomodulin (P<0.01), but not with 6-month restenosis.
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