Key result
Mild to moderate CKD is linked to ~27% higher aortic pulse wave velocity vs. healthy controls.
Why the study?
Pulse wave velocity has been widely assessed in end-stage renal disease but its behavior in mild to moderate chronic kidney disease has been less investigated.
Observational (n=31)
Absolute Event Rate: 7.95% vs 6.24%
p-value: p=0.03
Suggests increased arterial stiffness in mild-moderate CKD; hypothesis-generating and should not yet change practice.
BACKGROUND: In patients with end-stage renal disease pulse wave velocity (PWV) has been widely assessed, but its behavior in mild to moderate chronic kidney disease (CKD) has been less investigated. We evaluated PWV in mild to moderate CKD. METHODS: We studied 31 patients with grade II-IV CKD. Aortic PWV (aPWV), aortic and upper limb augmentation index, creatinine clearance, C-reactive protein, serum fibrinogen, interleukin-1, interleukin-6, tumor necrosis factor, albumin, total and high-density lipoprotein cholesterol and blood pressure were evaluated. RESULTS: aPWV (7.95 +/- 0.64 m/s), but not augmentation index was significantly higher (p = 0.03) in CKD patients than age-matched healthy subjects (aPWV: 6.24 +/- 0.43 m/s; upper limb: 32.8 +/- 1.9; aortic: 27.7 +/- 1.9). At univariate regression analysis, aPWV was significantly correlated with age (r = 0.44; p = 0.013), interleukin-6 (r = 0.43; p = 0.027), pulse (r = 0.39; p = 0.029), systolic blood pressure (r = 0.37; p = 0.038) and tumor necrosis factor (r = 0.39; p = 0.029). At multivariate analysis, pulse pressure was the only significant independent determinant (beta = 0.37; p = 0.05) of aPWV. CONCLUSION: The results of this study confirm an aPWV increase in mild to moderate CKD and emphasize association between pulse pressure and PWV, independently of renal failure.
No takes yet. Share an insight, caveat, or question.
Stancanelli et al. (2007) conducted an observational in Mild to moderate chronic kidney disease (n=31). Mild to moderate chronic kidney disease vs. Age-matched healthy subjects was evaluated on Aortic pulse wave velocity (aPWV) (p=0.03). Mild to moderate chronic kidney disease was associated with higher aortic pulse wave velocity than healthy subjects (7.95 vs 6.24 m/s; p=0.03), with pulse pressure as an independent determinant.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: