Key result
PulseSelect PFA peak frequencies >150 Hz signal effective tissue contact during CTI ablation.
Why the study?
Pulsed field ablation (PFA) near coronary arteries such as the cavotricuspid isthmus carries a risk of coronary artery vasospasm, and precise tissue proximity assessment during CTI ablation is critical for efficacy and safety.
Does peak frequency analysis guide effective tissue contact during cavotricuspid isthmus ablation using a straight-shaped pulsed field ablation catheter in patients with atrial flutter?
Case Report (n=2)
Does peak frequency analysis guide effective tissue contact during cavotricuspid isthmus ablation using a straight-shaped pulsed field ablation catheter in patients with atrial flutter?
Preapplication peak frequency analysis with a cutoff of 150 Hz may serve as a practical and robust indicator of adequate tissue contact during cavotricuspid isthmus ablation using a straight-shaped pulsed field ablation catheter.
May support frequency-based contact assessment during straight PFA catheter CTI ablation; hypothesis-generating pending prospective validation.
In recent years, pulsed field ablation (PFA) catheter-based treatment has become increasingly prevalent, with applications now extending beyond pulmonary vein isolation (PVI). The most widely used PFA catheter in the market is the Farapulse (Boston Scientific, Marlborough, MA, USA), which has been reported to demonstrate both high efficacy and safety.1 However, several studies have highlighted the potential risk of inducing coronary artery vasospasm.2 This risk is particularly pronounced when performing PFA applications near coronary arteries, such as in cavotricuspid isthmus (CTI) or mitral valve isthmus regions.
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Kawaji et al. (2025) conducted a case report in Atrial flutter during/after persistent atrial fibrillation ablation (n=2). PulseSelect PFA loop catheter (straight-shaped) with peak frequency-guided application was evaluated on Termination of atrial flutter and durable CTI block. High preapplication peak frequencies (>150 Hz) acquired by the straight-shaped PulseSelect PFA loop catheter indicated effective tissue contact for cavotricuspid isthmus ablation.
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