Key result
Prenatal exogenous sex hormone exposure is linked to ~8.5-fold higher risk of congenital heart disease.
Why the study?
The relationship between prenatal exposure to exogenous sex hormones and congenital heart disease was investigated to understand potential causes of malformations.
Case-Control (n=208)
Effect estimate: 8.5 times more common
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Hypothesis-generating for teratogenic risk; should not yet change prescribing without prospective confirmation.
Janerich et al. (1977) conducted a case-control in Congenital heart disease (n=208). Prenatal exposure to exogenous sex hormones vs. No exposure was evaluated on Congenital heart disease (malformations) (8.5 times more common). Prenatal exposure to exogenous sex hormones was 8.5 times more common among infants with congenital heart disease than among matched normal controls.
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