Key result
Atrial fibrillation was associated with significantly lower cognitive function compared to normal sinus rhythm, as measured by adjusted Mini-Mental State Examination scores (25.9 vs 27.6, p=0.013).
Why the study?
The factors influencing cognitive function in patients with atrial fibrillation remain unclear, including the relationship with CHA2DS2VASc score and stroke history.
Cross-Sectional (n=300)
No
Supports cognitive assessment in AF patients regardless of stroke history; leaves open causal links and therapeutic implications pending prospective data.
Background The factors that influence cognitive function in patients with atrial fibrillation (AF) remain unclear. Methods This study involved an AF group and control group (normal sinus rhythm) of 150 patients each. Cognitive function was assessed with the adjusted Mini-Mental State Examination (MMSEadj) score and Memory and Executive Screening (MES) score. The relationship between cognitive function and the CHA 2 DS 2 VASc score was analyzed. Subgroup analysis was performed according to stroke history. Clinical factors affecting the MMSE score were screened by logistic regression analysis. Results Baseline data were similar between the two groups. The MMSEadj and MES scores were significantly lower in the AF than control group; the mean MMSEadj score in the AF non-stroke subgroup and control non-stroke subgroup was 26.2 ± 2.7 and 27.9 ± 2.0, respectively. In non-stroke patients with AF, the MMSEadj and MES scores were negatively correlated with the CHA 2 DS 2 VASc score. Factors significantly influencing the MMSE score in these patients were age, education, smoking history, NT-proB-type natriuretic peptide, hemoglobin, and anticoagulation. Conclusion AF is associated with cognitive dysfunction regardless of stroke history. High CHA 2 DS 2 VASc scores are associated with impaired cognitive function. Factors influencing cognitive function in non-stroke patients with AF are age, education, smoking history, NT-proB-type natriuretic peptide, hemoglobin, and anticoagulation.
No takes yet. Share an insight, caveat, or question.
Xiong et al. (2019) conducted a cross-sectional in Atrial fibrillation (n=300). Atrial fibrillation vs. Normal sinus rhythm was evaluated on Adjusted Mini-Mental State Examination (MMSEadj) score (p=0.013). Atrial fibrillation was associated with significantly lower cognitive function compared to normal sinus rhythm, as measured by adjusted Mini-Mental State Examination scores (25.9 vs 27.6, p=0.013).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: