Key result
TTVR shows early feasibility as a potential therapy for severe tricuspid regurgitation.
Why the study?
There is an unmet need for percutaneous therapies for tricuspid regurgitation due to high surgical risk and recurrence rates with current surgical treatments.
Tricuspid regurgitation (TR) is a prevalent valve condition, with an estimated 1.6 million people in the USA living with moderate or greater severity. Functional TR, which predominantly develops due to left-sided heart disease, is the predominant condition affecting the tricuspid valve in the Western world and severe TR is associated with substantial morbidity and mortality. In part, due to a prolonged latency period with insidious symptoms, patients are often referred for surgery at advanced stages, with associated increased or prohibitive surgical risk. In addition, surgical treatment can result in high rates of recurrence. Therefore, there is an unmet need for percutaneous therapies that may provide a relatively low-risk treatment option. There are several devices with early human feasibility data available that will be reviewed in this article.
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Jabbour et al. (2017) conducted a review in Tricuspid regurgitation. Transcatheter tricuspid valve replacement (TTVR) was evaluated. Transcatheter tricuspid valve replacement is currently in an early stage of development, with initial human feasibility data demonstrating potential as a therapeutic option for severe tricuspid regurgitation.
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