Key result
On-pump CABG is linked to long-term cognitive dysfunction in ~68% of male patients.
Why the study?
The dynamics of neurophysiological parameters and the incidence of early and long-term postoperative cognitive dysfunction after on-pump coronary artery bypass grafting were not well characterized over 1 year.
Cohort (n=81)
No
High POCD rates in male on-pump CABG patients warrant vigilance; leaves open need for larger prospective studies.
Purpose. To study the dynamics of neurophysiological parameters in patients undergoing on-pump coronary artery bypass grafting 1 year follow-up. Materials and methods. Eighty-one patients with coronary artery disease (CAD) aged 47 to 68 years were included. All the patients underwent neuropsychological and electroencephalographic (EEG) study 3–5 days before, 7–10 days and 1 year after on-pump CABG. The cases of early and long-term postoperative cognitive dysfunction (POCD) were defined by arbitrary criterion, such as 20 % parameters decline in 20 % of tests of all neuropsychological test battery. High-resolution monopolar EEG recordings (62 channels) with closed and open eyes were made using encephalograph «NEUVO», Compumedics, USA. Artifact-free EEG fragments were divided into 2-s epochs and underwent Fourier transformation. EEG spectral power in the frequency band of 4–50 Hz were obtained. The data were log-transformed to normalize the distribution. Statistical processing was performed by using the t-test (Statistica 6.0). Results. The incidence of early POCD was 70 %, long-term POCD – 68 %, of which 51 % were patients with early POCD. The increase of low-frequency theta activity power was found at 7–10 days after CABG in the open and closed eyes, as well as alpha and beta1 activity power with eyes open. One year after CABG the power values of these rhythms decreased, but not reaching the baseline, and were higher than before surgery. Conclusion. The clinical manifestations of early and long-term POCD associated with signs of cortical dysfunction revealed by EEG dynamic changes after on-pump CABG 1 year follow-up.
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Tarasova et al. (2015) conducted a cohort in Coronary artery disease (n=81). On-pump coronary artery bypass grafting vs. Baseline (pre-surgery) was evaluated on Incidence of long-term postoperative cognitive dysfunction (POCD) at 1 year. In male patients undergoing on-pump coronary artery bypass grafting, the incidence of early postoperative cognitive dysfunction was 70% and long-term postoperative cognitive dysfunction at 1 year was 68%.
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