Key result
Genetic variation of the apolipoprotein B gene, specifically the XbaI polymorphism, is associated with elevated serum cholesterol levels but not with coronary artery disease among Finns.
Why the study?
The role of apolipoprotein B genetic variants in serum lipid regulation and coronary artery disease among Finns was not fully clarified.
Does not support genetic testing for apolipoprotein B variants; leaves open dietary lipid response modification in select populations.
The genetic variation of apolipoprotein B has been studied extensively in Finns with the aid of protein and DNA polymorphisms. Population association studies confirmed significant associations between the XbaI polymorphism of the apolipoprotein B gene and elevated serum cholesterol levels, and dietary studies suggested that the XbaI and ins/del polymorphisms might modify the serum lipid response to dietary fat intake. Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease. The results suggest that the apolipoprotein B gene is involved in the regulation of serum lipid levels. A yet unknown mutation in linkage disequilibrium with the XbaI site may contribute to this regulation.
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Tikkanen et al. (1992) conducted a review in Coronary artery disease and elevated serum cholesterol. Apolipoprotein B genetic variants (XbaI, ins/del, 3'VNTR) was evaluated on Serum lipid levels and coronary artery disease. Genetic variation of the apolipoprotein B gene, specifically the XbaI polymorphism, is associated with elevated serum cholesterol levels but not with coronary artery disease among Finns.
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