Key result
Specific apoB hypervariable alleles are linked to severe coronary heart disease and elevated lipid levels.
Why the study?
Previous reports have examined correlations between minor alleles of the apolipoprotein B gene and atherosclerosis or premature heart disease, but further investigation was needed.
Are specific hypervariable minisatellite alleles of the apolipoprotein B gene associated with severe coronary heart disease?
Population
110 patients with severe coronary disease and 117 normal controls
Comparison
Presence of alleles with 38, 44, 46, or 48 hypervariable elements vs absence of these alleles
Design
Case-control study
Authors
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These alleles may mark higher CHD risk; hypothesis-generating and should not yet change clinical practice.
Case-Control (n=227)
Are specific hypervariable minisatellite alleles of the apolipoprotein B gene associated with severe coronary heart disease?
Specific hypervariable minisatellite alleles of the apolipoprotein B gene are associated with severe coronary heart disease and altered lipid profiles.
Friedl et al. (1990) conducted a case-control in Coronary heart disease (n=227). Alleles containing 38, 44, 46, or 48 hypervariable elements near the apolipoprotein B gene vs. Normal controls was evaluated on Association with coronary heart disease. Alleles containing 38, 44, 46, or 48 hypervariable elements near the apolipoprotein B gene were associated with severe coronary heart disease and elevated serum lipid levels.
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