Key result
Beta-blockers linked to ~43% lower mortality in elderly post-MI survivors.
Why the study?
Beta-blockers are underused in elderly AMI survivors, and the associated determinants and adverse outcomes including mortality and rehospitalization require investigation.
Population
5332 elderly 30-day AMI survivors with prescription drug coverage in New Jersey Medicare population
Comparison
Beta-blocker use vs nonuse and calcium channel blocker use
Design
Retrospective cohort study using linked Medicare and drug claims data
Follow-up
2 years
Authors
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Beta-blocker underuse may worsen outcomes in elderly post-MI patients; leaves open whether RCT survival benefits apply to real-world Medicare cohorts.
Cohort (n=5,332)
Relative Risk: 0.57 (95% CI 0.47–0.69)
Stephen B. Soumerai (1997) conducted a cohort in Acute myocardial infarction (n=5,332). Beta-blockers vs. Nonrecipients was evaluated on Mortality (RR 0.57, 95% CI 0.47-0.69). Beta-blocker use in elderly survivors of acute myocardial infarction was associated with a 43% lower mortality rate compared to nonrecipients (RR 0.57; 95% CI 0.47-0.69).
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